William Hume
William Hume may refer to:
- Bill Hume (footballer), English-born soccer player who played for New Zealand and Australia
- Bill Hume (cartoonist), American artist, art director, and newspaper man
- Billy Hume, Scottish footballer
- Willie Hume, cyclist, first ever winner on Dunlop pneumatic tyres
- William Hume (Cape politician), politician of the Cape Colony
- William Errington Hume, English physician
- William H. Hume, American architect in New York City
- William J. Hume, American heir, businessman and conservative philanthropist
- William Fraser Hume, British geologist