William Hoffman
William Hoffman may refer to:
- William Hoffman (author), American novelist
- William Hoffman (painter), American painter
- William Hoffman (United States Army), American military officer, led the Colorado River Expedition of 1858–1859 against the Mohave
- William Hofmann, American Union Army officer during the American Civil War
- Sonny Hoffman, baseball player
- William F. Hoffmann (scientist), physicist at the University of Arizona who was awarded the status of Fellow from the American Physical Society
- William M. Hoffman, American playwright
- Bill Hoffman (American football), American football player
- Bill Hoffman (bowling), ten-pin bowler
- Bill Hoffman (baseball), American baseball player
- Billy Hoffman, American country music artist
- Bill Hoffman, one of the original developers of CMake and vice president of Kitware
- Bill Hoffman, candidate in the United States [House of Representatives elections in Washington, 2010#District 7|United States House of Representatives elections in Washington, 2010]