William Grimes
William Grimes may refer to:
- William Alvan Grimes, Chief Justice of the New Hampshire Supreme Court
- William C. Grimes, American politician and businessman
- William Grimes , former restaurant critic and current obituary writer for The New York Times
- W. F. Grimes, Welsh archaeologist
- William Grimes , English professional footballer for Bradford City and Derby County
- William Grimes , author of what is considered the first narrative of an American ex-slave, Life of William Grimes, the Runaway Slave
- William P. Grimes, American politician in Wisconsin
- Billy Grimes, American football player