William Clerke
William Clerke may refer to:
- William Clerke (MP), MP for Devizes, Wilton and Calne
- William Clerke (writer)
- Sir William Clerke, 2nd Baronet, of the Clerke baronets
- Sir William Clerke, 3rd Baronet, of the Clerke baronets
- Sir William Clerke, 5th Baronet, of the Clerke baronets
- Sir William Clerke, 8th Baronet, of the Clerke baronets
- Sir William Henry Clerke, 9th Baronet, of the Clerke baronets
- Sir William Henry Clerke, 10th Baronet, of the Clerke baronets
- Sir William Francis Clerke, 11th Baronet, of the Clerke baronets