William Cain

• William Cain , lieutenant governor of South Carolina
• William Cain , mayor of Melbourne and Victorian parliamentarian
• William Cain , Manx master mariner
• Sir William Cain, 1st Baronet, English brewer and philanthropist
• William Cain , Australian cricketer
• William Cain , Manx judge
• Bill Cain , American athletic director
• Bill Cain , player in Iowa State Cyclones men's basketball
• Bill Cain, American playwright