William Bruce
William Bruce may refer to:
- Sir William Bruce , Scottish architect
- William Bruce, 8th Earl of Kincardine, Scottish nobleman
- William Bruce , Australian cricketer
- William Bruce , physician and politician in Upper Canada
- William Bruce , posthumous recipient of the Victoria Cross
- William Cabell Bruce, author and United States Senator
- Major William Bruce-Gardyne of Clan Gardyne, Laird of Middleton, Angus, Scotland
- William Speirs Bruce, Scottish explorer
- William George Bruce, Milwaukee publisher, historian, and civic leader
- William Bruce , Irish Presbyterian and educator
- William Bruce , Irish Presbyterian and professor
- William Blair Bruce, Canadian painter
- William Napier Bruce, British educationalist and lawyer
- William J. Bruce III, American author and publicist