William Brereton
William Brereton may refer to:
- William Brereton (fl. 1406–1432), MP for Midhurst and Chichester
- William Brereton (courtier) in the privy chamber of Henry VIII
- Sir William Brereton (died 1559), MP for Cheshire in 1547 and 1559
- Sir William Brereton, 1st Baronet, Parliamentary General in the English Civil War
- William Brereton, 1st, 2nd and 3rd Lords Brereton
- * William Brereton, 1st Baron Brereton, MP for Cheshire in 1597, 1614 and 1621
- * William Brereton, 2nd Baron Brereton, MP for Cheshire in 1661
- * William Brereton, 3rd Baron Brereton, MP for Newton in 1659 and Bossiney 1660
- William Brereton (actor), English actor
- William Brereton (British Army officer), colonel in the Royal Horse Artillery
- William Brereton (priest), Archdeacon of Lichfield, 1782–1801
- William Brereton (planter), planter in British Guiana