William Appleton

• William Appleton (Massachusetts politician), American politician
• Will Appleton, mayor of Wellington, New Zealand
• W. A. Appleton, British trade union leader
• William Sumner Appleton, founder of the Society for the Preservation of New England Antiquities
• William M. Appleton, Pennsylvania politician
• William Henry Appleton, American publisher
• William Appleton (entrepreneur), American entrepreneur and technologist
• William H. Appleton, American soldier and Medal of Honor recipient
• William Thomas Appleton, Australian businessman, shipping agent and public servant