Wetzel
- Bernard C. Wetzel
- Blaine Wetzel
- Carl Wetzel
- Dan Wetzel
- David Wetzel
- Donald Wetzel
- Gary George Wetzel
- George P. Wetzel, Sr.
- Jake Wetzel
- John Wetzel (American football)
- John Wetzel (Pennsylvania official)
- John Wetzel (basketball)
- Julia Wetzel
- Karl Friedrich Gottlob Wetzel
- Lewis Wetzel
- Robert Lewis "Sam" Wetzel
- Susanne Wetzel
- Sylvia Wetzel
- Walter C. Wetzel
- Wetzel County, West Virginia
- Wetzel's Climbing Mouse
- Wetzel's Pretzels
- Wetzel, Michigan
- Wolfgang Wetzel