West Main Street Historic District
- East Main Street Historic District (disambiguation)
- Madison Square–West Main Street Historic District
- Main Street Historic District (disambiguation)
- National Register of Historic Places listings in Fairfield County, Ohio
- National Register of Historic Places listings in Grant County, Wisconsin
- National Register of Historic Places listings in Greenup County, Kentucky
- National Register of Historic Places listings in Huron County, Ohio
- National Register of Historic Places listings in Scott County, Kentucky
- North Main Street Historic District (disambiguation)
- South Main Street Historic District (disambiguation)
- West Main Street Commercial Historic District (Statesboro, Georgia)
- West Main Street District (Kent, Ohio)
- West Main Street Historic District (Charlottesville, Virginia)
- West Main Street Historic District (Chesterfield, South Carolina)
- West Main Street Historic District (Forest City, North Carolina)
- West Main Street Historic District (Lincolnton, North Carolina)
- West Main Street Historic District (Louisville, Kentucky)
- West Main Street Historic District (Marlborough, Massachusetts)
- West Main Street Historic District (Oconto, Wisconsin)
- West Main Street Historic District (Westborough, Massachusetts)
- West Main Street–West James Street Historic District