James Wadsworth
James Wadsworth may refer to:
- James Wadsworth (Jesuit), English Catholic priest and Jesuit
- James Wadsworth (Spanish scholar and pursuivant), son of the Jesuit
- James Wadsworth (lawyer), American jurist and politician
- James Wadsworth (of Geneseo), American pioneer and philanthropist
- James Wadsworth (mayor), American politician, mayor of Buffalo, New York
- James S. Wadsworth, American soldier
- James W. Wadsworth, American politician - House
- James W. Wadsworth Jr., American politician - Senate
- James Jeremiah Wadsworth, American diplomat