Vitamin D binding protein domain III


In molecular biology, Vitamin D binding protein domain III protein domain is predominantly found in Vitamin D binding proteins. Vitamin D-binding protein is synthesized primarily in the liver. This entry outlines the domain III of DBP. Domain III is G-actin binding region located in the C-terminal. Domain. This protein is found ubiquitously in vivo in significant quantities and can be detected in all fluid compartments. During acute phase inflammatory response, DBP levels tend to increase.

Function

DBP has several functions. More precisely, domain III has the specific function of being an extracellular scavenger for G-actin released from necrotic cells at sites of tissue injury.

Structure

DBP domain III has a multihelical structure. It is required for formation of an actin 'clamp', allowing the protein to bind to actin. This protein is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.