Virginia State Route 781
State Route 781 in the U.S. state of Virginia is a secondary route designation applied to multiple discontinuous road segments among the many counties. The list below describes the sections in each county that are designated SR 781.
List
| County | Length | Length | From | Via | To | Notes |
| Accomack | SR 679 | Taylor Farm Road | Dead End | - | ||
| Albemarle | SR 875 | Sunset Avenue Extension | Charlottesville city limits | - | ||
| Amherst | Dead End | Cash Town Road | SR 629 | - | ||
| Augusta | Dead End | Mill Race Road Bald Rock Road | SR 744 | - | ||
| Bedford | SR 644 | Tabernacle Lane | SR 621 | - | ||
| Botetourt | SR 658 | Westwood Court | Dead End | - | ||
| Campbell | Dead End | Mortimer Drive | SR 24 | - | ||
| Carroll | SR 713 | Locust Ridge Road | SR 620 | - | ||
| Chesterfield | Dead End | Granite Spring Road | US 60 | - | ||
| Fairfax | SR 1260 | Central Avenue Martha Street Martha Washington Street | SR 3122 | Gap between segments ending at different points along US 1 | - | |
| Fauquier | SR 705 | Rock Hill Road | SR 702 | - | ||
| Franklin | SR 40/SR 752 | Pernello Road Ramblin Rose Road | SR 865 | Gap between segments ending at different points along SR 623 | - | |
| Frederick | SR 1538 | Prince Frederick Drive | SR 780 | - | ||
| Halifax | Dead End | Deer View Trail | SR 678 | - | ||
| Hanover | SR 715 | Connie Hall Road | SR 674 | - | ||
| Henry | SR 688 | Chestnut Knob Road | Dead End | - | ||
| Loudoun | SR 9 | Catoctin Ridge Road | SR 9 | - | ||
| Louisa | Cul-de-Sac | Rescue Lane | SR 780 | - | ||
| Mecklenburg | SR 728 | One Mike Road | SR 49 | - | ||
| Montgomery | SR 655 | Lick Run Road | SR 708 | - | ||
| Pittsylvania | SR 626 | Rockcreek Road | SR 40 | - | ||
| Prince William | Dead End | Cushing Road | SR 621 | - | ||
| Pulaski | Dead End | Scott Road | SR 693 | - | ||
| Roanoke | Dead End | Crumpacker Drive | US 220 Alt | Gap between SR 1220 and SR 1226 | - | |
| Rockbridge | SR 759 | Unnamed road Petites Gap Road | Dead End | - | ||
| Rockingham | SR 613 | Wills Creek Road | SR 752 | - | ||
| Scott | SR 665 | Poplar Street | SR 767 | - | ||
| Shenandoah | SR 654 | County Farm Lane | Dead End | - | ||
| Stafford | Cul-de-Sac | Ballantrae Court | Cul-de-Sac | - | ||
| Tazewell | US 19 | Industry Road | US 19 | - | ||
| Washington | Bristol city limits | Tranbarger Road | SR 655 | - | ||
| Wise | US 23 | Hamner Hollow Road | SR 614 | - | ||
| York | SR 780 | Brook Run | SR 706 | - |