SR 413 begins at a cloverleaf interchange with US 29 Business and SR 86 west of downtown Danville. US 29 Business heads southwest along a continuation of Memorial Drive and north on Central Boulevard, which crosses over the Dan River and has another cloverleaf interchange with US 58 Business. SR 413 heads east as a four-lane divided highway, paralleling the south bank of the Dan River into the Danville Historic District. The state highway reaches SR 293 just south of the pair of bridges on which SR 293 crosses the river. The roadway continues as Craghead Street east toward the Danville station serving Amtrak's Crescent train. At Patton Street which carries the northbound lanes of SR 293, SR 413 ends.