Together with neighboring Mala Ligojna, Velika Ligojna was attested in written sources in 1309 as Luckossel. The medieval transcriptions indicate that the name was Lukosela in the 14th century, probably originally based on the name *Ľudigojь and then confused in the transcriptions with the similar name Luka. If so, today's name is a result of the sound changeľu- > li- and modern vowel reduction, and means 'Ljudigoj's village'.