VU-0238429
VU-0238429 is a drug which acts as a selective positive [allosteric modulator] for the Muscarinic acetylcholine [receptor M5|muscarinic acetylcholine receptor M5]. It was the first selective ligand developed for the M5 subtype, and is structurally derived from older M1-selective positive allosteric modulators such as VU-0119498. Replacing the O-methyl- by a phenyl group further improves the receptor subtype selectivity.