VSC
- Carchex
- Debreceni VSC
- ICAO airline designator (V)
- Microsoft App-V
- Missions of the United States Coast Guard
- Vaipuna SC
- Valley Stream Central High School
- Vancouver Sleep Clinic
- Variable structure control
- Variations in sex characteristics
- Vehicle Stability Control
- Venezuela Solidarity Campaign
- Vermont State Colleges
- Vermont Studio Center
- Versus programming language
- Vertebral subluxation complex
- Vertical service code
- Victory Services Club
- Video Standards Council
- Vietnam Solidarity Campaign
- Vinings, Georgia
- Virtual Safety Car
- Visual Studio Code
- Vitória Sport Clube
- Volatile sulfur compounds
- Voltage source converter
- Volume Shadow Copy Service
- Volunteer Special Constabulary
- Wake Forest University