VARS2Valyl-tRNA synthetase 2, mitochondrial is a protein that in humans is encoded by the VARS2 gene.FunctionThis gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. .