State Route 195 was created in 1935, running west and north from what was then the end of SR-108 in Syracuse through West Point to the then-end of SR-37 in Hooper. An extension of SR-37 cut back the north end of SR-195 to a point west of Clinton in 1945, and in 1947 the latter route was removed from the state highway system. The portion of SR-195 heading west from SR-108 was restored in 1965 as part of SR-127, and in 1969 a new SR-110 brought the remainder of old SR-195 back onto the system.