UPS
- Association of Biomolecular Resource Facilities
- Socialist Party of Senegal
- The UPS Store
- UPS Airlines
- Ubiquitin-proteasome system
- Ultraviolet photoelectron spectroscopy
- Underground Press Syndicate
- Uninterruptible power supply
- United Parcel Service
- United Photoplay Service
- Universal Pantheist Society
- Universal Polar Stereographic coordinate system
- Universal Press Syndicate
- University of Puget Sound
- Université Paul Sabatier
- Unpentseptium
- Ups (debugger)