List of ambassadors of the United States to Ghana
The following is a list of ambassadors of the United States to Ghana. The embassy in Accra was established March 6, 1957, with Donald W. Lamm in charge as chargé d'affaires. President Joe Biden nominated career U.S. diplomat and Acting Assistant Secretary/Principal Deputy Assistant Secretary of the Bureau of Energy Resources Virginia E. Palmer for the position on June 2, 2021.
Ambassadors
| Name | Title | Appointed | Presented credentials | Terminated mission | Notes |
| Donald W. Lamm – Career FSO | Chargé d'Affaires | March 12, 1957 | April 19, 1957 | ||
| Peter Rutter – Career FSO | Chargé d'Affaires | April 25, 1957 | June 19, 1957 | ||
| Wilson C. Flake – Career FSO | Ambassador Extraordinary and Plenipotentiary | May 20, 1957 | June 19, 1957 | November 21, 1960 | Reaccredited when Ghana became a republic |
| Francis H. Russell – Career FSO | Ambassador Extraordinary and Plenipotentiary | November 11, 1960 | January 23, 1961 | March 13, 1962 | |
| William P. Mahoney Jr. – Political appointee | Ambassador Extraordinary and Plenipotentiary | May 21, 1962 | June 22, 1962 | May 26, 1965 | |
| Franklin H. Williams – Political appointee | Ambassador Extraordinary and Plenipotentiary | October 20, 1965 | January 17, 1966 | May 3, 1968 | Reaccredited after change of government |
| Thomas W. McElhiney – Career FSO | Ambassador Extraordinary and Plenipotentiary | July 24, 1968 | September 14, 1968 | May 29, 1971 | |
| Fred L. Hadsel – Career FSO | Ambassador Extraordinary and Plenipotentiary | July 23, 1971 | September 25, 1971 | July 29, 1974 | |
| Shirley Temple Black – Political appointee | Ambassador Extraordinary and Plenipotentiary | September 19, 1974 | December 6, 1974 | July 13, 1976 | |
| Robert P. Smith – Career FSO | Ambassador Extraordinary and Plenipotentiary | October 4, 1976 | December 17, 1976 | May 7, 1979 | |
| Thomas W. M. Smith – Career FSO | Ambassador Extraordinary and Plenipotentiary | September 28, 1979 | December 12, 1979 | July 2, 1983 | |
| Robert E. Fritts – Career FSO | Ambassador Extraordinary and Plenipotentiary | July 6, 1983 | July 28, 1983 | June 2, 1986 | |
| Stephen R. Lyne – Career FSO | Ambassador Extraordinary and Plenipotentiary | March 27, 1987 | July 11, 1987 | September 9, 1989 | |
| Raymond Charles Ewing – Career FSO | Ambassador Extraordinary and Plenipotentiary | August 7, 1989 | November 9, 1989 | August 14, 1992 | |
| Kenneth Lee Brown – Career FSO | Ambassador Extraordinary and Plenipotentiary | July 14, 1992 | September 24, 1992 | July 19, 1995 | |
| Edward P. Brynn – Career FSO | Ambassador Extraordinary and Plenipotentiary | October 3, 1995 | December 19, 1995 | July 10, 1998 | |
| Kathryn Dee Robinson – Career FSO | Ambassador Extraordinary and Plenipotentiary | October 22, 1998 | December 16, 1998 | September 1, 2001 | |
| Nancy Jo Powell – Career FSO | Ambassador Extraordinary and Plenipotentiary | July 16, 2001 | September 14, 2001 | May 26, 2002 | |
| Mary Carlin Yates – Career FSO | Ambassador Extraordinary and Plenipotentiary | November 26, 2002 | January 28, 2003 | July 25, 2005 | |
| Pamela E. Bridgewater – Career FSO | Ambassador Extraordinary and Plenipotentiary | June 21, 2005 | October 11, 2005 | June 10, 2008 | |
| Donald G. Teitelbaum – Career FSO | Ambassador Extraordinary and Plenipotentiary | June 6, 2008 | September 9, 2008 | August 24, 2012 | |
| Gene A. Cretz – Career FSO | Ambassador Extraordinary and Plenipotentiary | April 11, 2012 | October 8, 2012 | June 26, 2015 | |
| Robert P. Jackson – Career FSO | Ambassador Extraordinary and Plenipotentiary | November 22, 2015 | February 4, 2016 | July 27, 2018 | |
| Stephanie S. Sullivan – Career FSO | Ambassador Extraordinary and Plenipotentiary | September 10, 2018 | January 23, 2019 | April 8, 2022 | |
| Virginia Palmer – Career FSO | Ambassador Extraordinary and Plenipotentiary | March 2, 2022 | May 10, 2022 | May 28, 2025 | |
| Rolf Olson – Career FSO | Chargé d'affaires ad interim | May 29, 2025 | Incumbent |