USC
- Adelaide
- Frasers Group
- Pontifical University of the Holy Cross
- Shih Chien University
- South Australian Amateur Soccer League
- UEFA Super Cup
- USC (clothing retailer)
- USC Canada
- USC Trojans
- Ubuntu Software Center
- Uchinoura Space Center
- Ullapara Science College
- Ulster Service Corps
- Ulster Special Constabulary
- Unified Soil Classification System
- Unitarian Universalist Service Committee
- United Shipbuilding Corporation
- United Soccer Coaches
- United Somali Congress
- United SportsCar Championship
- United States Code
- United States Congress
- United States Constabulary
- United States customary units
- Unity Sporting Club
- Universal Social Charge
- Universidad del Sagrado Corazón
- University Senior College
- University of San Carlos
- University of Santiago de Compostela
- University of Science and Culture
- University of South Carolina
- University of South Carolina System
- University of South China
- University of Southern California
- University of Southern Colorado
- University of the Southern Caribbean
- University of the Sunshine Coast
- Upper St. Clair High School
- Utica School of Commerce
- Utility Stores Corporation
- WWE United States Championship