UPR
- Popular Republican Union (disambiguation)
- Progressive Union for Renewal
- Ukrainian People's Republic
- Unconditional positive regard
- Unfolded protein response
- Unia Polityki Realnej
- Union Pacific Railroad
- Union for Progress and Renewal (Guinea)
- Unitary parliamentary republic
- Universal Periodic Review
- University of Puerto Rico
- University of Puerto Rico at Aguadilla
- University of Puerto Rico at Arecibo
- University of Puerto Rico at Bayamón
- University of Puerto Rico at Carolina
- University of Puerto Rico at Cayey
- University of Puerto Rico at Humacao
- University of Puerto Rico at Mayagüez
- University of Puerto Rico at Ponce
- University of Puerto Rico at Rio Piedras
- University of Puerto Rico at Utuado
- University of Puerto Rico, Medical Sciences Campus
- Utah Public Radio