UFC Fight Night: Cowboy vs. Gaethje

Background

A lightweight bout between former UFC Lightweight Championship challenger Donald Cerrone and former WSOF Lightweight Champion Justin Gaethje served as the event's headliner.
A middleweight bout between former WSOF Middleweight and Light Heavyweight Champion David [Branch (fighter)|David Branch] and The Ultimate Fighter: Team Joanna vs. Team Cláudia light heavyweight winner Andrew Sanchez was scheduled for the event. However, it was reported that Branch was forced to pull out of the event due to injury and was replaced by Marvin Vettori. In turn, it was reported that Sanchez was forced to pull out of the event due to an eye infection, resulting in cancellation of the bout. In turn, the pairing was left intact and was rescheduled a month later at UFC Fight Night: Joanna vs. Waterson.
A welterweight bout between Michel [Pereira (fighter)|Michel Pereira] and Sergey Khandozhko was scheduled for the event. However, it was reported that Khandozhko was removed from the card due to visa issues. He was replaced by promotional newcomer Tristan Connelly. At the weigh-ins, Pereira weighed in at 172 pounds, 1 pound over the welterweight non-title fight limit of 171. He was fined 20% of his purse and his bout with Connelly proceeded at a catchweight.

The following fighters received $50,000 bonuses.