Twomile Creek
- Randolph County, North Carolina
- Two Mile Creek (Yellow River tributary)
- Twomile Creek (Chattahoochee River tributary)
- Twomile Creek (East Branch Oil Creek tributary)
- Twomile Creek (Kanawha River)
- Twomile Creek (Marmaton River)
- Twomile Creek (Nepco Lake tributary)
- Twomile Creek (North Fork Salt River)
- Twomile Creek (Uwharrie River tributary)
- Twomile Creek (Warm Fork Spring River)