The districtdates back to the Oberamt Tuttlingen, which was created in 1806. After several minor changes it was merged with the Oberamt Spaichingen and converted into the district in 1938. In 1973, it was enlarged by some municipalities from the dissolved districts Donaueschingen and Stockach.
Mining
From an old 3.5 km mine in a Doggererzflöz in Weilheim is wood in the Tuttlinger Fruchtkasten. Steel was produced in Tuttlingen by the Schwäbische Hüttenwerke in Ludwigshal. The furnace in Harras was closed in 1832. By building railways new calculations make the ironore of the area unprofitable. After the Franco-Prussian Warmining was stopped.