Tuffy
- Bazooka Joe
- Dan Tuffy
- Earl Abell
- Harold "Tuffy" Stratton
- Joanna Tuffy
- Lady and the Tramp
- Lil Tuffy
- Nibbles (Tom and Jerry)
- The Smurfs
- Toughie (disambiguation)
- Tuff (disambiguation)
- Tuffy Conn
- Tuffy Gosewisch
- Tuffy Griffiths
- Tuffy Knight
- Tuffy Leemans
- Tuffy Maul
- Tuffy Nabors
- Tuffy Neugen
- Tuffy Rhodes
- Tuffy Stewart
- Tuffy Stone
- Tuffy Thompson