Trichocereine
Trichocereine, or trichocerine, also known as N,N''-dimethyl-3,4,5-trimethoxyphenethylamine or as N,N''-dimethylmescaline, is a phenethylamine alkaloid that is found in several cacti and other plant species and is closely related to the psychedelic drug mescaline.
Use and effects
In contrast to mescaline, trichocereine has been found to lack psychoactive effects in humans even at large doses. F. P. Ludueña assessed trichocereine hydrochloride in the mid-1930s and found that it produced no effects, with the exception of slight gastric heaviness, at doses of up 9mg/kg orally and up to 550mg parenterally. Vojtĕchovský and Krus assessed trichocereine in the 1960s at doses of up to 800mg and found that they were weaker than those of 400mg mescaline. They also tried 400mg sublingually and reported that it produced moderate psychedelic effects with a one-hour onset and a "proportionally shorter" duration than mescaline or a duration of one hour. Per Alexander Shulgin however, these psychoactive effects were ill-defined and it was felt that they might have been attributable to anxiety.Shulgin has noted that Trichocereus terscheckii, which contains trichocereine as its major constituent, is commonly consumed in large amounts by humans and animals as a water source without obvious consequences. It has been noted that N-methylation of psychedelic phenethylamines, for instance Beatrice, has invariably eliminated their hallucinogenic activity.