Transcriptome‐wide association studies accounting for colocalization using Egger regression
Transcriptome‐wide association studies accounting for colocalization using Egger regression is a scholarly work by Richard Barfield, published in 2018 in ''Genetic Epidemiology''. The main subjects of the publication include association, RNA splicing, genomics, biology, regression, colocalization, and Genomic selection. The authors derive the standard TWAS approach in the context of MR and show in simulations that the standard TWAS does not control type I error for causal gene identification when eQTLs have pleiotropic or LD‐confounded effects on disease.