Tomatidine
Tomatidine is a natural compound found in leaves of tomatoes and green tomatoes. Chemically, it is the aglycone of tomatine. It has been shown to have potential health benefits in animal models. For instance, tomatidine inhibited skeletal muscle atrophy in a mouse model of skeletal unloading-induced atrophy and to prevent or reverse sarcopenia by inhibiting the activation of genes by ATF4.
Dietary supplementation with ~0.04% tomatidine for 10 weeks reduced plasma cholesterol and atherosclerosis in ApoE-deficient mice without evidence of toxicity.