The station was opened on 1 August 1841 by the Great North of England Railway. The first site of the station was situated southeast of Sykes Lane Bridge and the second site was situated northwest of Sykes Lane Bridge. A goods yard was provided to the northwest end of the old sidings. In 1937, Tollerton's services were reduced significantly to the point that there were no feasible provisions for people commuting from work in York. Sunday services ceased in 1943. Another passenger service from York to Pickering ceased on 2 February 1952, leaving only two services on the timetable; two morning services to and from Edinburgh. This station managed to survive the purge of stations on the main linenorth of York in 1958, the reason for this being unclear. It was later closed on 1 November 1965, to both passengers and goods traffic.