On 2 August 2017, Khoza and other members of the portfolio committee on basic education were conducting oversight visits at schools in the Cape Winelands area until the vehicle they were travelling in collided with a minibus taxi and overturned on the R301 between Paarl and Franschhoek. Khoza was fatally injured, while three other MPs sustained serious injuries. President Jacob Zuma extended condolences to Khoza's family. A memorial service was held for him at Mbambiso High School in Boschfontein on 10 August 2017; his funeral was held two days later.