| Year | Event type | Event | Disease name | Geographic location |
| 16th century BC | | Schistosome parasites thought to first evolve in the Great Lakes of East Africa around this period. | Schistosomiasis | Africa |
| 16th century BC | | Guinea Worm is described in several ancient Egyptian texts, and is thought to be common in the area | Dracunculiasis | Egypt |
| 1st Century – 7th Century | Discovery | Roman and Byzantine physicians are familiar with human roundworms and tapeworms and the infections that they cause. | Roundworm, tapeworm | Roman Empire |
| 1683–1684 | Discovery | Birth of modern helminthology. Detailed anatomy of the roundworm is described, first by English physician Edward Tyson, and shortly afterward by the Italian Francesco Redi. | Roundworm | England, Italy |
| 1799–1801 | Crisis | Napoleon's soldiers almost certainly suffer from haematuria caused by schistosomiasis infection. | Schistosomiasis | |
| 1851 | Discovery | Theodor Bilharz discovers the parasite responsible for schistosomiasis. | Schistosomiasis | |
| 1882 | Publication | First mention of schistosomiasis in The Lancet. | Schistosomiasis | |
| 1883 | | Interest in schistosomiasis heightens in England due to more frequent encounter with the disease following English occupation of Egypt. | Schistosomiasis | England, Egypt |
| 1893–1918 | Program launch | Four commissions designed to understand schistosomiasis are sent to North Africa. | Schistosomiasis | Africa |
| 1898 | Discovery | Scientist Arthur Looss discovers that hookworms enter the body by boring through the skin when he accidentally infects himself. | Hookworm | |
| 1909 | Organization | The Rockefeller Sanitary Commission for the Eradication of Hookworm Disease is founded. One of RSC's main goals is to eradicate hookworm disease in Southern United States. The RSC is active from 1910 to 1914, and closes in 1915. It is replaced by the International Health Division, another Rockefeller Foundation initiative, which tackled public health concerns on a global level. | Hookworm | United States |
| 1914–1934 | | Overdose of oil of chenopodium, administered as part of the Rockefeller hookworm eradication program, causes over 200 documented deaths. More than 80% of deaths occur in children under 12. | Hookworm | |
| 1915 | Discovery | Robert Thomson Leiper works out the life-cycle of schistosomiasis. | Schistosomiasis | |
| 1926–1931 | Successful eradication | Guinea Worm is eradicated in Uzbekistan through a series of health education and sanitation measures. | Dracunculiasis | Uzbekistan |
| 1927–1951 | | Attempts are made to kill the intermediate hosts for schistosomiasis using copper sulfate instead of sanitation and health education. The reasoning here is to prevent the schistosomiasis life-cycle from being completed. However it is unclear if these measures reduced the prevalence of schistosomiasis. | Schistosomiasis | |
| 1938 | | Schistosomiasis Commission proposed by Hilmy Bey; the League of Nations Health Committee suggests more research on the disease, but nothing is done due to the imminence of World War II. | Schistosomiasis | |
| 1939–1945 | Crisis | Allied soldiers affected by schistosomiasis in China, the Philippines, and the Pacific Islands. This brings the disease to international attention. | Schistosomiasis | |
| 1942 | Program launch | Schistosomiasis control program begins in Venezuela. | Schistosomiasis | Venezuela |
| 1947 | Publication | First assessment of the distribution of schistosomiasis in the world by Norman Stoll. | Schistosomiasis | |
| 1948 | Program launch | The first World Health Assembly decides to establish an "Expert Committee" to deal with schistosomiasis. | Schistosomiasis | |
| 1949 | Program launch | Volunteer organizations for deworming form in Tokyo and Osaka, which implement "biannual school-based mass screening and treatment". | Soil-transmitted helminthiasis | Japan |
| 1955 | Program launch | Japan Association of Parasite Control forms. JAPC is a consolidation of several previous deworming groups that existed. | Soil-transmitted helminthiasis | Japan |
| 1965–1995 | Program launch | Korea Association for Parasite Eradication models their deworming program off Japanese programs. | Soil-transmitted helminthiasis, hookworm, etc. | South Korea |
| 1971 | Successful eradication | Iran eliminates dracunculiasis. | Dracunculiasis | Iran |
| mid-1980s | | Under Japan Association of Parasite Control, deworming efforts lead to "very minimal levels" of Ascaris. | Soil-transmitted helminthiasis | Japan |
| 1986–present | Organization | The Carter Foundation begins a campaign to eradicate Guinea worm. The incidence of guinea worm infection declines sharply, from an estimated 3.5 million cases in 1986 to 22 reported cases in 2015. | Dracunculiasis | |
| 1997 | | The World Health Organization declares South Korea "essentially worm-free". | Soil-transmitted helminthiasis | South Korea |
| 2001 | | The World Health Assembly declares the goal of 75% of schoolchildren in endemic areas receiving deworming treatment. | Schistosomiasis, Soil-transmitted helminthiasis | |
| 2002 | Organization | The Schistosomiasis Control Initiative established after being funded by the Bill & Melinda Gates Foundation. Since 2013 SCI has been a GiveWell top charity. | Schistosomiasis | |
| 2007 | Organization | Deworm the World Initiative is founded. Since 2014 Deworm the World Initiative has been a GiveWell top charity. | Soil-transmitted helminthiasis | |
| 2012 | Program launch | Various organizations announce a coordinated effort to eliminate or control 10 neglected tropical diseases, including both schistosomiasis and soil-transmitted helminthiasis. | Schistosomiasis, soil-transmitted helminthiasis | |
| 2015 | | The "deworming debate" takes place starting in July on whether deworming is effective. | | |