Time-resolved mass spectrometry
Time-resolved mass spectrometry is a strategy in analytical chemistry that uses mass spectrometry platform to collect data with temporal resolution. Implementation of TRMS builds on the ability of mass spectrometers to process ions within sub-second duty cycles. It often requires the use of customized experimental setups. However, they can normally incorporate commercial mass spectrometers. As a concept in analytical chemistry, TRMS encompasses instrumental developments, methodological developments, and applications.
Applications
An early application of TRMS was in the observation of flash photolysis process. It took advantage of a time-of-flight mass analyzer.TRMS currently finds applications in the monitoring of organic reactions, formation of reactive intermediates, enzyme-catalyzed reactions, convection, protein folding, extraction, and other chemical and physical processes.