TilisololTilisolol is a beta blocker.SynthesisThe methanolysis of Phthalic anhydride gives Methyl hydrogen phthalate . Schotten-Baumann amidation with Methyl sarcosinate gives Methyl 2-benzoate, PC11644670. Intramolecular lactamization with sodium methoxide afforded Methyl 4-hydroxy-2-methyl-1-oxoisoquinoline-3-carboxylate, PC54684295. In lye saponification followed by decarboxylation occurred to give 4-hydroxy-2-methylisoquinolin-1-one . Treatment with Epichlorhydrin in the presence of base led to 2-Methyl-4-isoquinolin-1-one . Opening of the oxirane ring with tert-Butylamine completed the synthesis of Tilisolol.