Thiopurine

Thiopurine is an analogue of a purine wherein a C=O/C-OH group has been replaced by a C=S/C-SH group. These organosulfur compounds are bioactive in beneficial and complicating manner. They interfere with purine biosynthesis. Thiopurine drugs antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders, and organ transplant recipients. Azathioprine is a prodrug. 6-Mercaptopurine is substrate for three enzymes: thiopurine methyltransferase, xanthine oxidase. They are also substrates for nudix hydrolase 15.

Controversy

Litigation over patents covering diagnostic kits to monitor the dosing of these drugs led to a US Supreme Court case, Mayo Collaborative Services v. Prometheus Laboratories, Inc. that dramatically changed the nature of patent law in the United States.