Thelocactus multicephalus is a small perennial gray-greencactus that grows in clusters, growing 6 - tall and is between in diameter. It has conical tubercles. The areoles have 4 to 5 central spines are long that are grey, radial spines are absent. Flowers, about long, are funnel-shaped and white and rarely light pink, growing from new growth at the top of the plant. Seeds are long.