SCO
- Aktau Airport
- Angers SCO
- Bluetooth protocols
- Microbial oil
- SCO Group
- SCO OpenServer
- Santa Cruz Operation
- Scoot
- Scorpius
- Scotland
- Scots language
- Scottish Chamber Orchestra
- Selected Characteristics of Occupations
- Self-checkout
- Shanghai Cooperation Organisation
- Singapore Chinese Orchestra
- Single Cell Orchestra
- Society of Canadian Ornithologists
- South Coast Line
- Southern College of Optometry
- Special Communications Organization
- Subcommissural organ
- Swedish Chamber Orchestra
- Syllabus
- Synthetic crude
- United States Office of Special Counsel (disambiguation)