LSE
- La Crosse Regional Airport
- La Crosse station
- Lahore School of Economics
- Lahore Stock Exchange
- Landing ship
- Language-Sensitive Editor
- Least-squares estimation
- Lengua de signos española
- Lincoln Southeast High School
- Load serving entity
- Logical Sensory Extrovert
- London School of Economics
- London Stock Exchange
- London Stock Exchange Group
- Louvain School of Engineering
- Luzern–Stans–Engelberg railway line
- Lysergic acid ethylamide
- RAID