The book follows Dr. Warthrop, a scientist trying to debunk theories that vampires could possibly exist. He's drawn from his research by his former fiancé, who pleads with him to save her husband from the flesh eating Wendigo. Not believing that such a creature could exist, Warthrop ventures out and succeeds in saving his ex's husband, only for the man to then transform into a Wendigo himself. Warthrop and Will Henry are then forced to hunt and destroy the creature.