The Curious Case of Pyrexia of Unknown Origin
The Curious Case of Pyrexia of Unknown Origin is a scholarly work, published in 2018 in ''Medical Journal of Clinical Trials & Case Studies''. The main subjects of the publication include therapeutic hypothermia, fever of unknown origin, and Streptococcus pyogenes. Pyrexia of unknown origin (PUO) is a diagnostic challenge for many clinicians.The causes of PUO are diverse.Infections and malignancies are the most common causes of PUO.There are many rare causes of PUO like aorto-arteritis, Stills disease, sarcoidosis, and temporal arteritis.However, extensive diagnostic tests are required for diagnosis in some cases.We had a 47-year-old lady who presented to us as a rare case of PUO.After extensive investigations she was diagnosed as a case of Idiopathic Hemophagocytic Lymphohistiocytosis (HLH).HLH is a rare disease with high mortality.Most frequently the diagnosis of HLH is missed.