Gnanamma started a school for girls in Phirangipuram in 1862. Two young women, Arulamma and Agathamma, joined her in her social work in 1871. Gnanamma talked with the parish priest about forming a congregation of nuns and sent young women to train under the Sisters of the Congregation of the Good Shepherd, Bellary. She started two congregations, one at Madras and another at Phirangipuram. Her congregations came into existence after her death.