The name and boundaries of the district were first proposed on 24 July 1902 by the chief draftsman, with the spelling "Thadoona". It was later altered to Thaduna, and gazetted accordingly on 4 March 1903. It was later adjusted to make the rabbit-proof fence the eastern boundary of the district. On 17 June1960, its spelling was changed to "Thadoona" to better conform with the correct Aboriginal pronunciation of the name.