Terpene synthase C terminal domain


In molecular biology, this protein domain belongs to the terpene synthase family. Its role is to synthesize terpenes, which are part of primary metabolism, such as sterols and
carotene, and also part of the secondary metabolism. This entry will focus on the C terminal domain of the TPS protein.

Function

Terpenes synthases have a role in producing important molecules in metabolism, these molecules are part of a large group called terpenoids. In particular, the C terminal domain catalyzes the cyclization of geranyl diphosphate, orienting and stabilizing multiple reactive carbocation intermediates. Or in simpler terms, the C terminal aids the synthesis of new molecules.

Structure

It is thought to have at least two alpha helices.

Conservation

Sequences containing this protein domain belong to the terpene synthase family. It has been suggested that this gene family be designated tps. Sequence comparisons reveal similarities between the monoterpene synthases, sesquiterpene synthases and the diterpene synthases. It has been split into six subgroups on the basis of phylogeny, called Tpsa-Tpsf.