SR 373 begins in Maury [County, Tennessee|Maury County] at an intersection with Tennessee [State Route 50|SR 50] a few miles southeast of Columbia. It heads south as Culleoka Highway through farmland as a two-lane highway to pass through Culleoka, where it makes a sharpturn to the east. The highway winds its way east through more hilly terrain for a few miles to cross into Marshall County. SR 373 winds its way through rural hilly countryside for several more miles as Mooresville Highway, where it has an interchange with I-65 and widens to a four-lane undivided highway, before enteringLewisburg at an intersection with SR 417. The highway becomes W Commerce Street and passes through neighborhoods for several miles before entering downtown. SR 373 then comes to an end at the courthousesquare at an intersection with U.S. [Route 31A Business|US 31A Business]/U.S. [Route 431Business (Lewisburg, Tennessee)|US 431 Business]/SR 11/SR 50.
History
The entire route of SR 373 was originally designated as State Route 50A. It was renumbered, as many of Tennessee's alternate routes were, to SR 373 during the 1983 [Tennessee state highway renumbering|1983 renumbering].