SR 359 begins at an interchange with I-26/US 19W/US 23 exit 27. From this interchange, SR 359 travelseastward to South Roan Street; it then turnsnorth onto, and merges with, South Roan Street for to an intersection where South Roan Street continues north and SR 359 turns northeast and continues a north-northeast track to MilliganHighway. SR 359 turns east on to Milligan Highway and continues a northeasterly track until it ends at an intersection with US 321/SR 67.