SR 336 begins at an intersection with US 411 just east of Greenback. It travels south through farmland as Brick Mill Road to the community of Lanier, where it has an intersection with US 129. The highway turnsnortheast through hilly and wooded terrain as 6 Mile Road to the community of Six Mile, where it makesa sharp left at an intersection with Montvale Road and Old Piney Road. SR 336 goes north to pass through a ridge as Montvale Road before passing through farmland and suburbs to enter Maryville. It passes through neighborhoods before coming to an end at an intersection with US 321.