Tennessee State Route 159
State Route 159 is a west to east highway in the U.S. state of Tennessee that is 12 miles long. It begins in Carter [County, Tennessee|Carter County] at State [Route 67 |State Route 67] and ends in Johnson County at the North Carolina state line. State Route 159 is little-known by the general public by this designation as it is overlain by U.S. Route 321; the "159" designation is seen on mileposts.