SR 105 turns east and heads towardRutherford, where it has an interchange with US 45W/SR 5. It then passes through downtown, where it runs along Trenton Street, the former route of US 45W. The highway then leaves Rutherford and continues east to cross the Rutherford Fork of the Obion River and have an intersection with SR 445. SR 105 then turns southeast and begins to run parallel South Fork of the Obion River as it enters Bradford, where it has an intersection with US 45E/SR 43 and a concurrency with SR 54 through downtown. The highway then leaves Bradford and winds its way southeast to cross into Carroll County.