TauD protein domain


In molecular biology, TauD refers to a protein domain that in many enteric bacteria is used to break down taurine as a source of sulfur under stress conditions. In essence, they are domains found in enzymes that provide bacteria with an important nutrient.

Function

This protein family consists of TauD/TfdA taurine catabolism dioxygenases. The Escherichia coli tauD gene is required for the utilization of taurine as a sulfur source and is expressed only under conditions of sulfate starvation. TauD is an alpha-ketoglutarate-dependent dioxygenase catalyzing the oxygenolytic release of sulfite from taurine. The 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase from Burkholderia sp. also belongs to this family. TfdA from Ralstonia eutropha is a 2,4-D monooxygenase.

Structure

This structure has a number of alpha helices and beta sheets.